Analytical resolution of parallel and antiparallel oligonucleotide triple helices formation and melting processes by means of Multivariate Curve Resolution
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منابع مشابه
Resolution of a structural competition involving dimeric G-quadruplex and its C-rich complementary strand
The resolution of the dimeric intermolecular G-quadruplex/duplex competition of the telomeric DNA sequence 5'-TAG GGT TAG GGT-3' and of its complementary 5' ACC CTA ACC CTA-3' is reported. To achieve this goal, melting experiments of both sequences and of the mixtures of these sequences were monitored by molecular absorption, molecular fluorescence and circular dichroism spectroscopies. Molecul...
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Intramolecular triple helices have been obtained by folding back twice oligonucleotides formed by decamers bound by non-nucleotide linkers: dA10-linker-dA10-linker-dT10 and dA10-linker-dT10-linker-dA10. We have thus prepared two triple helices with forced third strand orientation, respectively antiparallel (apA*A-T) and parallel (pA*A-T) with respect to the adenosine strand of the Watson-Crick ...
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Back in 1957, when investigators produced a triple-stranded form of DNA while studying synthetic nucleic acids, few researchers paid much attention to the discovery. However, triplex DNA was never entirely forgotton and especially since 1987 its structural and functional importance in biological systems as well as its medical applications and therapeutic potentional have been extensively studie...
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تاریخ انتشار 2015